Glossary
Hepatic Risk
Updated February 28, 2026
Hepatic risk means your stack may be more likely to stress your liver, especially with multi-ingredient stacks or concurrent medications.
Why it matters
Unfair uses this term when it sees warning patterns from ingredients and user context that could indicate liver burden and advises caution before continuing.
Early warning signs
Stop and seek urgent care if you notice:
- yellowing eyes or skin
- dark urine, pale stool, severe fatigue with nausea, vomiting, or right-upper abdominal pain
- persistent itching, fever, or new confusion
If no severe symptoms, request clinician review when any two occur:
- labs suggest ALT or AST greater than 3× upper-limit normal
- you report new GI tenderness plus fatigue for more than 72 hours
- bilirubin rises above roughly 2× upper-limit normal or you have dark urine with clay-colored stool
High-risk categories to monitor more closely
- Regular heavy alcohol use
- frequent acetaminophen exposure or known liver stress history
- anabolic or hepatotoxin-heavy stacks, including repeated "detox/cleansing" blends
- transplant history or transplant-prescription overlap
- known hepatitis, cirrhosis, or prior unexplained ALT elevation
Stop and test triggers in Unfair
- When severe sign appears: immediate pause command, plus alerting messaging and clinician contact prompt.
- With repeated mild warning signs: temporary hold of hepatically active supplements for 48 hours and symptom trend review.
- After 1–2 consecutive high-risk signals: stack suggestion quality is reduced until updated labs or clinician input is logged.
Practical action step
If you already use a high-risk combination, create a 7–10 day stability window before changes: log doses, sleep, energy, and any jaundice or abdominal symptoms daily, then review before resume.
Uncertainty and limits
- Evidence is limited on dose thresholds for mixed botanical stacks in real-world self-reported environments.
- Evidence is limited on how long transient fatigue alone should delay escalation without biochemical confirmation.
Cross-site references
How this appears in Unfair
You’ll see hepatic risk as stronger guardrails around dose ceilings, higher conservative ranking, and explicit prompts to hold compounds with overlapping liver burden.
Clinical safety note
If severe symptoms appear, this is a medical priority: pause non-essential supplements immediately and contact a clinician or urgent care for evaluation.