Intervention & Evidence Library
The Unfair Supplement Library
Searchable supplement profiles with outcomes, dosing guidance, safety notes, and study-backed evidence for faster protocol review.
384
Supplements
40
Categories
1190
Studies
Mar 18, 2026
Last Updated
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Adderall
Adderall is a prescription mixed amphetamine-salt stimulant for ADHD and narcolepsy. It is used clinically to improve attention, impulse control, and daytime wakefulness.
Alcohol
Alcohol refers to ethanol, a psychoactive compound in beverages. It is sometimes used for relaxation, but it also affects sleep, liver metabolism, and cardiometabolic risk.
Armodafinil
Armodafinil is the R-enantiomer of modafinil and a prescription wakefulness agent. It treats excessive sleepiness disorders and supports sustained alertness during the day.
Berberine
Berberine is a plant alkaloid that affects glucose and lipid metabolism through AMPK-related pathways and gut signaling. It is used for blood sugar and cardiometabolic support.
Biotin
Biotin (vitamin B7) is a cofactor for enzymes involved in fatty acid and glucose metabolism. It is used to address deficiency-related hair, skin, and nail problems.
Caffeine
Caffeine is a stimulant that blocks adenosine receptors and increases alertness. It is used to improve vigilance and to enhance endurance performance by lowering perceived exertion.
Calcium
Calcium is an essential mineral for skeletal structure, muscle contraction, and nerve signaling. It is used to support bone density when dietary intake is inadequate, often alongside vitamin D.
Chloride
Chloride is an essential electrolyte and a component of gastric hydrochloric acid. It is used to support fluid balance and digestion, particularly when losses occur through heavy sweating or illness.
Copper
Copper is an essential trace mineral required for energy production, antioxidant enzymes, connective tissue crosslinking, and iron handling. It is used to correct deficiency, often when zinc intake is high.
CoQ10
Coenzyme Q10 is a fat-soluble mitochondrial cofactor needed for electron transport and antioxidant defense. It is used for heart function support, migraine prevention, and statin-associated symptom mitigation.
Creatine
Creatine supports rapid ATP regeneration as phosphocreatine in muscle and brain. It is used to increase strength and power output and to support lean mass gains with resistance training.
DHA
DHA is an omega-3 fatty acid concentrated in the brain and retina. It is used to support neurodevelopment and visual function and to contribute to triglyceride lowering in low intake diets.
Donepezil
Donepezil is a prescription acetylcholinesterase inhibitor used in Alzheimer’s disease. It is used to modestly improve cognitive symptoms and daily functioning by increasing cholinergic signaling.
EPA
EPA is an omega-3 fatty acid with anti-inflammatory actions and triglyceride lowering effects. It is used for cardiometabolic risk marker improvement and, in some cases, mood symptom support.
Fiber
Fiber reliably supports bowel regularity and can improve LDL cholesterol when dosed consistently
Fluoride
Fluoride strengthens tooth enamel by promoting remineralization and inhibiting acid-producing bacteria. It is used primarily for caries prevention through topical exposure and, less commonly, systemic intake.
Ginger
Ginger (Zingiber officinale) contains gingerols and shogaols with antiemetic and anti-inflammatory activity. It is used for nausea relief, digestive comfort, and joint pain support.
Iodine
Iodine is required for thyroid hormone synthesis and normal growth and neurodevelopment. It is used to correct low iodine intake, particularly in pregnancy and in low seafood or iodized salt diets.
Iron
Iron is essential for hemoglobin, oxygen transport, and cellular energy metabolism. It is used to correct low ferritin or iron deficiency anemia that causes fatigue, poor exercise tolerance, and cognitive symptoms.
Kava
Kava (Piper methysticum) contains kavalactones that influence GABA-related signaling. It is used for anxiety symptom reduction and for sleep improvement secondary to reduced anxious arousal.
Lactase enzyme
Lactase enzyme helps digest lactose and reduce lactose-intolerance symptoms.
Lavender
Lavender oil, particularly the standardized preparation Silexan, has strong clinical evidence for reducing anxiety comparable to low-dose benzodiazepines, without sedation or dependence risk.
Lutein
Lutein is a carotenoid concentrated in the macula and brain. It is used for eye health, visual performance, and as part of strategies to slow age-related macular degeneration progression.
Magnesium
Magnesium is an essential mineral involved in neuromuscular function and hundreds of enzymes. It is used to correct low intake and to support sleep, cramps, migraine prevention, and blood pressure control.
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