Contraindication

Updated February 22, 2026

A contraindication means a specific ingredient or combination is likely unsafe enough to avoid, at least in the current context.

Why it matters

Unfair uses contraindication rules to prevent recommendation paths that are clearly inconsistent with your current profile.

Absolute contraindication: do not use without direct prescriber approval because harm risk is high.
Relative contraindication: use only with close tracking, adjusted dosing, and often temporary caution.

Relative flags can be useful in tightly controlled contexts, but absolute flags usually disable auto-recommendation in Unfair workflows.

Cardiovascular: stimulant-heavy combinations, vasoactive compounds, and BP-sensitive ingredients.
Pregnancy: hormone-sensitive and teratogenic-risk compounds depending on context and local guidance.
Renal/hepatic: compounds with high metabolism burden, especially with existing enzyme stress or reduced function.
Psychiatric medication overlap: serotonergic stacks and certain sedating/wake-promoting combinations.

Suppressed: items that match absolute-level risk are removed from active recommendations.
Label as requires confirmation: relative risks stay visible with explicit user confirmation and stronger prompts.

Evidence is limited for direct mapping of all herbal classes into absolute versus relative status for every patient profile.
Evidence is limited on uncommon comorbidity combinations due low representation in community datasets.

Contraindications map into warning tiers, suppression logic, and confirmation gates before recommendation delivery.

When absolute-risk flags are present, pause activation and confirm with a clinician before continuing.