Titration is a controlled step-up plan used to find effective dose while limiting adverse overload.
Why it matters
Start low, then increase in defined steps with enough observation for interpretation.
Stepwise protocol
Use this pattern:
- start dose for a fixed baseline window
- hold for 2–5 days, track outcomes
- add one step only when outcomes are stable
Pause rules
- pause on persistent GI, anxiety, insomnia, or adverse cardiovascular signs
- revert one step if the previous level created notable side effects
Plateau endpoint
Pause escalation when:
- benefit flattens across two logs
- side effects rise faster than benefit
- adherence reliability drops significantly
Practical action step
Keep only one changing variable at a time and keep full logs for at least 2–3 holding windows.
Uncertainty and limits
- Evidence is limited on exact titration intervals for every compound class.
- Evidence is limited on real-world plateau timing during multi-compound protocols.
Cross-site references
How this appears in Unfair
Titration logs are used to delay unsafe escalations and favor conservative steps when signals are mixed.
Clinical safety note
If symptoms escalate rather than improve, stop titration and consult a clinician.