A COMT variant is a genetic difference in the COMT gene that may inform hypotheses about catecholamine metabolism, stress response, or sensitivity patterns without predicting behavior by itself.
What COMT does
COMT encodes catechol-O-methyltransferase, an enzyme involved in breaking down catecholamines such as dopamine, norepinephrine, and epinephrine. The commonly discussed Val158Met variant can be associated with different enzyme activity ranges, but that does not translate cleanly into a fixed personality type or supplement response.
Where the signal can help
COMT context may be useful when a user repeatedly logs sensitivity to stimulation, sleep disruption, or mood volatility after similar inputs. Even then, the genotype is weaker than observed response, medication context, dose timing, and correlation metadata.
What not to infer
A COMT variant should not be read as proof that someone is high dopamine, low dopamine, resilient, anxious, or uniquely suited to a specific stack. Those claims collapse a complex stress and neurotransmitter system into one SNP, which is not enough evidence for a personal conclusion.
Relation to stack ranking
For Unfair, COMT belongs in the same bucket as cautious personalization context. It may lower confidence in aggressive assumptions, prompt more conservative language, or encourage closer tracking of timing. It should not choose ingredients by itself.
How this appears in Unfair
Unfair can use COMT as an explanatory note when logged patterns already point toward sensitivity. The active model should still prioritize observed tolerability, personalization weight, and safety flags over genotype.
Safety note
If sensitivity patterns involve severe anxiety, palpitations, insomnia, or medication overlap, the next step is clinical context, not more genotype interpretation.